“Efficacy of Combination drug therapy of Oxybutynin and Desmopressin in enuresis in children in comparison to one drug therapy or any other combination drug therapy : A Systematic review and Meta-analysis”

Background: This Systematic review was undertaken to bring forward some solution the old stubborn neglected problem of enuresis in children which appears be left out race scientific advancements. The pathogenesis disease so far understood is supposed result three factors Polyuria, Overactive bladder and difficulties arousal from sleep. However pinpointing extent role each one an individual case a difficult time resource consuming job. aim study help front line clinicians decision making poor limited developing countries, that families are not abandoned suffer on their own without any hope for speedy solution, when they come asking help. Methods: We hypothesized combination therapy Desmopressin oxybutynin usual therapeutic doses at outset, might solution. To accumulate evidence extensive search done as per PRISMA 2020 guideline properly designed double blind Randomized clinical trials back up such decision. Databases searched were PubMed, Embase, Google Scholar, Scopus web science. Clinical trial registry platforms, open access grey areas cross references also searched. Data obtained analyzed by random effect model , 95% confidence interval with Mantel Haenszel test risk ratio. Protocol registered PROSPERO Results: There lack robust randomized data nodal network meta-analysis. Nine studies included analysis having experimental or Intervention arm versus mono drug comparator. Synthesis meta-analysis using Cochrane Revman version 5.4 comparison Oxybutynin Imipramine therapy, hence discussed tabular form only other combinations new entrants armamentarium against like Tolterodine, Solifenacin, Propiverine. A favorable outcome observed this outset whatever we found, but bias there superiority can said marginal. More needed researchers different pharmacological therapies decrease gap point seeking control enuresis. Conclusion: recommend countries tackle stigmatized socially unacceptable present. will generating more favor future reference analysis. But say fraternity still behind blinded clear based medicine entity. Bangladesh Journal Medical Science Vol. 21 No. 04 October’22 Page : 685-697